In recent years, e-learning has become a valuable tool for an increasing number of visually impaired (VI) learners. The benefits of this technology include: (1) remote learning for VI students; (2) the possibility for teachers living far from schools or universities to provide remote instructional assistance to VI students; and (3) continuing education for VI adults. A number of studies confirm that VI students appreciate the advantages of e-learning systems, but they also have to face several challenges in pursuing their education through the e-learning mode. E-learning can be a valuable opportunity for VI users if suitable education methods and appropriate technologies are used. Hence, it is crucial to identify the needs and requirements of the target community in order to create a system that fulfils their expectations. This article describes the experiences of Indian VI learners with e-learning, throws light on the problems often encountered by them when using assistive technology and proposes guidelines for designers in order to develop more accessible e-learning systems.