This paper presents a quasi-experimental design to study the Effectiveness of Game Based Learning strategies for enhancing Achievement and Interest in Mathematics among the Middle School Students. Two groups were formed, one experimental group and another control group. Pretests of both the groups were taken and then the experimental group was taught using Game based learning strategies and the control group was taught using traditional methods. Post tests were conducted on both the groups and the achievement scores were calculated. Interest inventory was administered on the experimental group to understand the effectiveness of game based learning strategies qualitatively. This study illustrated methods to design and execute Game Based Learning strategies in Mathematics subjects to help students develop holistically.